Adopting a low-to-moderate risk posture, researchers are proceeding with targeted validation of epigenetic biomarkers despite an Expression of Concern that has raised some alarms. The evidence indicates that epigenetic alterations are consistently tied to various health issues, from traumatic brain injury to cancer progression, while foundational studies continue to support their role as both biomarkers and therapeutic targets. Cross-laboratory replication and transparent data practices will be prioritized to ensure robust findings.
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“We investigated genome-wide DNA methylation changes induced by chronic risperidone administration in the common marmoset, a non-human primate with high translational relevance. Adult males were treated orally with risperidone for 28 days.”
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“Traumatic brain injury (TBI) occurs when an external mechanical force damages brain tissue.”
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“Emerging evidence indicates that epigenetic and epitranscriptomic mechanisms, including histone modifications, DNA methylation, and RNA modifications, play pivotal roles in the molecular response to TBI.”
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“we highlight preclinical interventions that modulate these alterations and improve related post-TBI behavioral outcomes.”
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“the blots showing β‑actin mRNA expression in Fig. 1 on p. 1341 appeared to be similar to the β‑actin mRNA blots shown in Fig. 3 on p. 1342”
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“the authors were contacted by the Editorial Office to offer an explanation for this apparent anomaly in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming.”
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“we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further.”
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“Microcystin-LR (MC-LR), a potent cyanobacterial toxin found in freshwater ecosystems, has been linked to multisystem toxicity.”
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“However, its impact on renal pathology - particularly through regulated cell death - remains poorly characterized.”
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“Using both acute and chronic MC-LR exposure paradigms, marked kidney fibrosis and ferroptosis are observed.”
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“Pharmacological inhibition of DNA methyltransferases (SGI-1027) or ferroptosis (ferrostatin-1) significantly ameliorated renal injury.”
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“Emerging evidence links prenatal phthalate (PAE) exposure to offspring cardiovascular risks, yet mechanisms underlying early-life hypertension remain elusive.”