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Epigenetics of Childhood Obesity.
“Future research will undoubtedly discover numerous methylation sites that may be involved in the development of obesity and its comorbidities, especially at a young age.”
Epigenetics of Childhood Obesity.
“Although MRS are very promising for predicting the individual risk of obesity, the implementation of MRS is challenging and has not been introduced into clinical practice so far.”
Epigenetics of Childhood Obesity.
“Epigenome-wide association studies helped identify novel targets and methylation sites that are important in the pathophysiology of obesity.”
Epigenetics of Childhood Obesity.
“Childhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life.”
Non-canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets.
“However, recent publications have identified novel redox-based signalling pathways, and therefore novel drug targets, that may exert epigenetic effects.”
Non-canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets.
“The development of pharmacological agents that modulate the activity of major epigenetic proteins are in pre-clinical development and clinical use.”
Non-canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets.
“As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.”
Non-canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets.
“DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function.”
Construction of methylation-associated nomogram for predicting the recurrence-free survival risk of stage I-III lung adenocarcinoma.
“We successfully identified a DNA methylation-associated nomogram which can predict recurrence-free survival in patients with stage I-III lung adenocarcinoma.”
Construction of methylation-associated nomogram for predicting the recurrence-free survival risk of stage I-III lung adenocarcinoma.
“By receiver operating characteristic analysis, we showed the high ability of the 14-site methylation signature for predicting recurrence-free survival.”
Construction of methylation-associated nomogram for predicting the recurrence-free survival risk of stage I-III lung adenocarcinoma.
“We identified a 14-site methylation signature that was correlated with recurrence-free survival of stage I-III lung adenocarcinoma patients.”
A hitchhiker's guide to single-cell epigenomics: Methods and applications for cancer research.
“the development of several single-cell methods to profile diverse chromatin features has propelled the study of cancer epigenomics.”
A hitchhiker's guide to single-cell epigenomics: Methods and applications for cancer research.
“the role of epigenetic variation in cancer progression is still largely unexplored.”
Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates.
“There was no difference in IGFBP-1 gene methylation rate between the two groups of neonates and no correlation was observed with anthropometry.”
Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates.
“Gene expression level correlated with anthropometric measurements.”
Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates.
“Gene expression analysis showed significantly higher IGFBP-1 gene expressions among IUGR compared to AGA neonates.”
Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates.
“IUGR neonates had significantly lower anthropometry (weight, length and head circumference) measurements at birth compared to AGA neonates.”
Epigenomics-guided precision oncology: Chromatin variants in prostate tumor evolution.
“Ultimately, this review aims to support a new era of precision oncology, utilizing insights from epigenomics to improve prostate cancer patient outcomes.”
Epigenomics-guided precision oncology: Chromatin variants in prostate tumor evolution.
“These variants... are considered the fundamental units of epigenomic heterogeneity.”
Epigenomics-guided precision oncology: Chromatin variants in prostate tumor evolution.
“As cellular plasticity is largely driven by non-genetic events, complementary studies in cancer epigenomics are now being conducted.”