Recent findings confirm the reliability of DNA methylation-based epigenetic clocks, particularly DNAmGrimAge and DNAmPhenoAge, as strong predictors of mortality independent of age. The well-defined InCHIANTI study cohort from Tuscany supports a unified narrative across multiple research pillars, establishing these clocks as critical tools for health interventions. Additionally, stress reporting disparities between genders contextualize health outcomes, enhancing the understanding of how behavioral factors affect mortality predictions.
“We found that faster increases in several clocks were linked robustly to higher risk of death, independent of baseline epigenetic age and other confounders.”
“These findings suggest that dynamic changes in epigenetic aging reflect evolving health status and may serve as sensitive indicators for interventions aimed at extending healthspan and longevity.”
“Early in the 2010s, the Hannum clock and Horvath clock were developed, combining information on percent methylation in selected DNA sites to obtain a score that best correlated with chronological age.”
“In this study, we found that, after adjustment for baseline epigenetic clock and independent of chronological age and sex, changes in most epigenetic clocks predict differential mortality.”
“The models that included both baseline and longitudinal change for DNAmGrimAge v.2, DNAmGrimAge, DNAmPhenoAge and DunedinPACE had the highest C-statistics (Concordance index: 0.808 for DNAmGrimAge v.2).”
“Higgins-Chen and colleagues showed that DNAmPhenoAge and DNAmGrimAge had a stronger association with mortality than the Hannum clock and Horvath clock, even after improving their reliability using new computational techniques.”
“Our study demonstrates that longitudinal trajectories of epigenetic clocks can serve as reliable tools in observational studies to detect health changes driven by biological or environmental factors linked to mortality.”
“Our results provide evidence that longitudinal changes in epigenetic clock values reflect meaningful changes in health.”
“The InCHIANTI study participants were recruited from two Chianti regions of Tuscany, Italy (1998–2000).”
“we used Cox regression to examine the relationships between standardized values of epigenetic clocks and mortality across three models...”
“D.W.B. is an inventor of the DunedinPACE epigenetic clock, a Duke University and University of Otago invention licensed to TruDiagnostic.”
“he is consulting CSO and SAB chair of BellSant”