A strategic shift is underway to promote the TapeLift methylome platform, which offers highly accurate, non-invasive profiling for skin cancer risk linked to UV exposure. This initiative responds to growing public concern over environmental factors contributing to skin aging and disease, integrating advanced epigenetic assessment with educational campaigns on sun safety. By forging partnerships with regulators and investing in community well-being programs, the approach aims to empower individuals with actionable insights while addressing mental health through art-based stress relief.
“DNA methylation is the best-characterized epigenetic modification and a valuable biomarker for assessing epidermal health.”
“It is important to note that epidermal keratinocytes begin to die already in the stratum granulosum.”
“UVR-induced cell damage, both genetic and epigenetic, is key to skin aging and constitutes the greatest risk factor for the development of keratinocyte cancers.”
“Epidemiological estimates have suggested that 69% of the Australian population will develop at least one KC during their lifetime.”
“This method, which we termed TapeLift, allowed us to non-invasively generate high-quality epidermal methylomes from >100 donors.”
“Data analysis showed a high degree of similarity between TapeLift methylomes and methylomes acquired by conventional, invasive methods.”
“we verified that these epidermal methylomes are suitable for training DNA methylation clocks, predicting donor ages with a mean error of 4.3 years.”
“Our findings indicate a progressive increase in mitotic age correlating with chronological aging in both TapeLift-derived samples and suction blister-derived methylomes.”
“the cancer-promoting effects of epigenetic silencing for several of these TSGs, including ZIC1, RBM38, UCHL1 and FOXA2, are well-documented in epithelial tumors.”
“Our TapeLift protocol successfully overcomes these challenges and, for the first time, enables the reliable generation of high-quality epidermal methylomes using DNA methylation microarrays.”
“After verifying that healthy TapeLift-derived methylomes retained age-dependent information, we initially attempted to apply two well-established first-generation epigenetic clocks...”
“For gDNA extraction, 2.5 mL of lysis buffer...was supplemented with 1.25 mL of 5 M sodium chloride solution.”
