Charles River Laboratories (CRL) reported Q1 2026 sales of $995.8 million and a non-GAAP profit of $2.06 per share, both of which exceeded market expectations. However, the company is contending with pressures on its profit margins, as it experienced a 1.5% year-on-year decline in organic revenue. In response to its robust performance, CRL has raised its full-year adjusted EPS guidance to $11.05 at the midpoint and signed a significant MOU with MEDIPOST to enhance GMP testing solutions.