Recent analysis confirmed a Low-risk classification for downstream applications regarding prenatal psychosocial stress and DNA methylation research, enabling immediate policy formulation without conflict. This decision follows a coherent narrative linking environmental stressors to biological aging and emphasizes the urgent need to address the repercussions of socioeconomic factors on maternal-infant health outcomes.
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“Prenatal psychosocial stress is linked to adverse maternal-infant outcomes, plausibly via stress-responsive endocrine pathways and epigenetic regulation.”
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“For FKBP5, intron 7 (k = 2) showed lower DNAm with greater trauma/PTSD burden (SMD = -0.36, 95 % CI -0.67 to -0.05; I² ≈ 0 %).”
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“Prenatal stress is associated with detectable yet context-dependent epigenetic variation in peripheral tissues.”
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“Adverse childhood experiences (ACEs) are common, co-occurring risk factors for poor long-term health.”
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“Men exhibited higher GrimAge EAA than women across all groups.”
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“Among Black and White women, Financial Adversity was associated with elevated GrimAge EAA and a faster DunedinPoAm pace compared to the Low Adversity group.”
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“Among Hispanic women, Socioeconomic Adversity was linked to higher PhenoAge EAA and faster DunedinPoAm pace relative to those in the Parental Low Education group.”
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“The panel demonstrated strong diagnostic performance, achieving an AUC of 0.907 (95 % CI: 0.876-0.933), with a sensitivity of 83.9 % (95 % CI: 77.0-89.4 %) and a specificity of 88.5 % (95 % CI: 84.1-92.1 %).”
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“Importantly, it exhibited high diagnostic efficacy for early stage HCC, achieving sensitivities of 75.0 % for stage I and 84.0 % for stage II.”
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“These findings suggest that the DNA methylation biomarkers panel could revolutionize HCC diagnostics by enabling earlier, more accurate, and cost-effective detection, particularly in high-risk populations.”
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“we conducted whole-genome bisulfite sequencing and RNA sequencing on potato cultivar Qingshu No.9 inoculated with P. infestans.”
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“Hypomethylation changes at 12 h post-inoculation (hpi) were followed by hypermethylation at 24 hpi.”
