AstraZeneca has revealed plans to directly list its shares on the New York Stock Exchange beginning February 2, 2026, while maintaining its presence in London and Stockholm. This initiative, driven by the company's U.S. operations that accounted for 43% of its total revenue last year, includes a commitment to invest $50 billion in U.S. manufacturing by 2030. However, the company faces challenges, including a halted £200 million investment in its Cambridge site and pressure to reduce drug prices for U.S. patients.