“Given the absence of overt contradictions across the four pillars, we see that AI-driven segmentation currently serves as a powerful tool but remains provisional until more orthogonal validations are layered in. The field should therefore treat ‘Cell Segmentation’ as a hybrid construct: grounded in real cellular boundaries yet vulnerable to algorithmic bleed and boundary ambiguity. Future work must prioritize targeted benchmarking—leveraging nuclear‐specific markers and manual annotations—to verify that computational boundaries track true biological ones.”