With less than half of health care workers vaccinated against the updated COVID-19 vaccine, health authorities are rolling out targeted outreach and incentive programs to boost uptake. This hesitancy risks waning immunity as the world looks ahead to the promising development of broad-spectrum vaccines designed to combat multiple pathogens, expected to deliver results in the next three to five years. The urgent need to increase current vaccination rates is critical to provide immediate protection while the next generation of vaccine technology matures.